Understanding Overactive Bladder
Overactive Bladder (OAB) is a condition where the bladder contracts uncontrollably, creating leakage, the strong sudden need to "go right away," and going too often.
So what exactly is going on?First, it's important to realize that OAB is not a “weak” bladder. In fact, OAB occurs when nerves are affected. These nerves send signals to your bladder at the wrong time, causing the muscle to squeeze without warning. This process causes your bladder to spasm uncontrollably, creating leakage, the strong sudden need to “go,” and going too often.
How well-controlled are your OAB symptoms?
Coping with symptoms isn't the same as controlling them
Many with OAB still have symptoms such as:
- Going too often
- The strong and sudden need to "go"
Signs that you're just coping with OAB include:
Have you already tried OAB medications?
Did you discover that oral medications:
- Didn't work well enough OR
- Were too difficult to tolerate?
If this sounds familiar, you are not alone.
BOTOX® is a recommended option to reduce daily leakage episodes
The American Urological Association (AUA) treatment guidelines list BOTOX® as an appropriate therapy to consider discussing with your doctor when:
- Self-management is not effective (for example, using pads, or drinking less liquids)
- Oral medications do not work well enough or are too difficult to tolerate
If OAB medication isn't working or you can't take it because of intolerable side effects, you may be ready for BOTOX®.
BOTOX® is approved to treat Overactive Bladder symptoms — such as a strong need to urinate, along with leakage, urgency, and frequency — in adults when another type of medication (anticholinergic) does not work well enough or cannot be taken.
BOTOX® has been used in:
people with Overactive Bladder
since its FDA approval in 2013*
Could BOTOX® be right for you?
Find a BOTOX® Urology Specialist
OAB control for people who have already tried another OAB therapy
CALM YOUR BLADDER
Another approach to Overactive Bladder treatment.
BOTOX® is different from other treatments.
BOTOX® is injected into the bladder muscle to target the source of your OAB.
- In your body, certain chemicals travel from nerve cells to muscle cells to make your bladder contract so that you can urinate
- For people who have OAB, these muscles contract uncontrollably, creating leakage, the strong sudden need to go, and going too often
BOTOX® was proven to reduce daily leakage episodes
Average decrease in leakage episodes in 3 clinical trials 3 months after treatment, compared to placebo.
BOTOX® reduced daily leakage episodes by half or more
At week 12 in clinical trials:
Reduction of Urinary Incontinence (UI) episodes in:
placebo n = 277
- Patients with ≥ 50% reduction: BOTOX® 57.5%, placebo 28.9% (P < 0.001)
- Patients with ≥ 75% reduction: BOTOX® 44.6%, placebo 15.2% (P < 0.001)
- Patients with 100% reduction: BOTOX® 22.9%, placebo 6.5% (P < 0.001)
placebo n = 271
- Patients with ≥ 50% reduction: BOTOX® 63.5%, placebo 33.2% (P < 0.001)
- Patients with ≥ 75% reduction: BOTOX® 47.3%, placebo 20.3% (P < 0.001)
- Patients with 100% reduction: BOTOX® 31.4%, placebo 10.3% (P < 0.001)
placebo n = 60
- Patients with ≥ 50% reduction: BOTOX® 77.2%, placebo 33.3% (P < 0.001)
- Patients with ≥ 75% reduction: BOTOX® 55.2%, placebo 21.7% (P < 0.001)
- Patients with 100% reduction: BOTOX® 33.8%, placebo 11.7% (P < 0.001)
BOTOX® may positively impact your daily life by reducing daily leakage episodes
Based on results from a questionnaire, patients in BOTOX® clinical trials reported improvement in their overall quality of life in three categories*:
*These improvements were reported using the Incontinence Quality of Life questionnaire (iQOL). This is a validated questionnaire that is used to measure the impact of urinary incontinence on a patient's quality of life.